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ea0063gp199 | Adrenal and Neuroendocrine - Clinical | ECE2019

LC-MS/MS measurement for urinary aldosterone improves primary aldosteronism screening

Travers Simon , Blanchard Anne , Cornu Erica , Faucard Catherine , Baffalie Laurence , Azizi Michel , Houillier Pascal , Amar Laurence , BARON Stephanie

Objective: Primary aldosteronism (PA) is the first cause of endocrine hypertension accounting for about 6% of all cases of hypertension. According to international guidelines, PA screening is based on plasma aldosterone-to-renin concentration ratio (ARR) computation. Nevertheless, measurement of urine aldosterone excretion may be of interest since it integrates aldosterone secretion over 24 hours. However, available urine aldosterone immuno-assays have poor specificity.<p ...

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ea0063p465 | Adrenal and Neuroendocrine Tumours 2 | ECE2019

Measurement of metanephrine in adrenal venous sampling may help subtyping primary aldosteronism

Baron Stephanie , Bailly Clement , Cornu Erica , Blanchard Anne , Bergerot Damien , Pagny Jean-Yves , Laffy Pierre-Yves , Carrere Thierry , Grataloup Christine , Zinzindohoue Franck , Reznik Yves , Azizi Michel , Billaud Eliane , Amar Laurence

Objective: Adrenal venous sampling (AVS) is the gold standard method to assess lateralization of aldosterone secretion in patients with primary aldosteronism (PA). The selectivity index (SIcortisol, the adrenal to peripheral vein ratio of cortisol concentrations) determines correct catheter positioning during AVS. The lateralization index (LIcortisol, the aldosterone to cortisol ratios between adrenal veins) distinguishes unilateral aldosterone producing ...

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Endocrine Abstracts

LC-MS/MS measurement for urinary aldosterone improves primary aldosteronism screening

Measurement of metanephrine in adrenal venous sampling may help subtyping primary aldosteronism

BiosciAbstracts